Eddie is a parody of David Berkowitz, known as the Son of Sam. Niko does various activities for Eddie in exchange for money. During the last meeting in an alleyway, Eddie becomes angry at Niko and comes at him with a knife. Niko then ends up killing Eddie in self-defense. On the Liberty Tree Website, there are articles about murders that have occurred throughout Liberty City, many of which were committed by him.
Eddie Low has an entry in the LCPD Database. He has been criminally charged in the past for public lewdness and exposure.
In Grand Theft Auto V, there is an easter egg referencing Eddie. When listening to the CB radio in Trevor's Bodhi, a truck driver named Eddie Low will check in. Other listeners on the radio will mock Eddie for having the same name as a serial killer, much to his chagrin.